`Acute renal failure
- Bloody stools
- Breath odour- Ammonia breath
- Due to buildup of waste in the body
 
- Ammonia breath
- Bruising easily- Platelet dysfunction
 
- Platelet dysfunction
- Prolonged bleeding
- Changes in mental status or mood- Anaemia 
 
- Anaemia 
- Decreased apetite- Due to buildup of waste in blood
 
- Due to buildup of waste in blood
- Decreased sensation, especially in the hands or feet
- Fatigue- Decreased erythropoietin synthesis
- Anaemia
 
- Decreased erythropoietin synthesis
- Flank pain (between the ribs and hips)- Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause pain.
 
- Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause pain.
- Hand tremor
- High blood pressure- Fluid overload
 
- Fluid overload
- Metallic taste in mouth- Accumulation of uremic toxins
 
- Accumulation of uremic toxins
- Nausea or vomiting, may last for days- Accumulation of uremic toxins
 
- Accumulation of uremic toxins
- Persisent hiccups- Due to GI disturbance
 
- Due to GI disturbance
- Nosebleeds- Due to accumulation of toxic products
 
- Due to accumulation of toxic products
- Seizures- Hypocalcaemia
- because the impaired kidney no longer produces calcitriol and because hyperphosphatemia causes Ca phosphate precipitation in the tissues
 
- Hypocalcaemia
- Slow, sluggish movements
- Swelling-generalised- fluid retention
 
- fluid retention
- Swelling of the ankle, feet, and leg swelling- Fluid retention
 
- Fluid retention
- Urination changes- Decrease in amount of urine
- Excessive urine at night (nocturia)- Peripheral oedema (abnormal infiltration of tissues with blood fluids) may be reabsorbed when the patient lies down in bed at night.
 
- Peripheral oedema (abnormal infiltration of tissues with blood fluids) may be reabsorbed when the patient lies down in bed at night.
- Urination stops completely (end stage)
 
- Decrease in amount of urine
- Shortness of breath- Fluid retention in lungs
- anemia
 
- Fluid retention in lungs
 
 
 
 
Chronic renal failure
Initial symptoms
- Fatigue- Decreased erythropoietin synthesis
 
- Decreased erythropoietin synthesis
- Frequent hiccups- GI disturbances
 
- GI disturbances
- General ill feeling- Potassium accumulates in the blood
 
- Potassium accumulates in the blood
- Generalised itching- Pruritis
- Due to buildup of waste in blood
 
- Pruritis
- Headache
- Nausea, vomiting- Due to accumulation of uremic toxins
 
- Due to accumulation of uremic toxins
- Unintentional weight loss- Due to loss of appetite
 
- Due to loss of appetite
Later symptoms
- Blood in the vomits or in stools
- Decreased alertness, including drowsiness, confusion, delirium, or coma- anemia
 
- anemia
- Decreased sensation in the hands, feet, or other areas
- Easy bruising and bleeding- Platelet dysfunction 
 
- Platelet dysfunction 
- Increased or decreased urine output
- Muscle twitching or cramps- Hypocalcaemia
 
- Hypocalcaemia
- Seizures- hypocalcaemia
 
- hypocalcaemia
- White crystals in and on the skin (uremic frost)- Due to accumulation of urea in the body
 
- Due to accumulation of urea in the body
Additional symptoms
- Abnormally dark or light skin- Due to increased melanin production
 
- Due to increased melanin production
- Agitation
- Breath odour- Ammonia breath
- Due to buildup of waste in body
 
- Ammonia breath
- Excessive nighttime urination (nocturia)
- Excessive thirst- High level of urea in the blood
 
- High level of urea in the blood
- High blood pressure- Fluid overload
 
- Fluid overload
- Loss of apetite- accumulation of uremic toxins
 
- accumulation of uremic toxins
- Nail abnormalities- Due to increased melanin production
 
- Due to increased melanin production
- Paleness- anemia
 
- anemia
 
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